我認(rèn)為你首先要明確對(duì)方向你要proposal的目的是什么？對(duì)方首先是想通過你的研究計(jì)劃看你發(fā)現(xiàn)問題，分析問題以及提出解決方法的能力。這里面牽涉到的問題很多：
    1、你的proposal是否具有創(chuàng)新性，你對(duì)當(dāng)前國際最新的研究進(jìn)展是否熟悉，你有無自己的思路？
    2、你提的計(jì)劃是否結(jié)合你自己和對(duì)方的背景知識(shí)，是否具有可行性？
    3、你的計(jì)劃是否充分完備，是否提供備用方案，也就是說你是否充分估計(jì)了你計(jì)劃實(shí)施的困難？
    呵呵，上面說的三條看起來有些空洞。但是寫作組織起來并不復(fù)雜。
    第一段，背景介紹，充分閱讀相關(guān)最新的文獻(xiàn)（04、05年的），提出科學(xué)問題；
    第二段，簡要分析你的主要思路及意義；
    第三——？段，制定相關(guān)研究計(jì)劃，不需要具體的每步的細(xì)節(jié)，但是你的論述應(yīng)該讓對(duì)方認(rèn)為你對(duì)該細(xì)節(jié)有著充分了解和認(rèn)知，并非天馬行空似的漫談；
    最后一部分，分析你的Proposal中潛在問題，并進(jìn)一步提出潛在方案。
    我想如果對(duì)方發(fā)現(xiàn)你的思路如此明確，即使方案在他看來還比較naive或者premature，他也會(huì)對(duì)你另眼相看的。
    What's the purpose of a research plan?
    It depends on who's asking the question, and who’s answering it. From your immediate point of view the purpose of a research plan is to help get you hired.
    The research plan, though, serves another, very important function: It contributes to your development as a scientist. Your research plan is a map for your career as a research science professional. As will become apparent later in this document, one of the functions of a research plan is to demonstrate your intellectual vision and aspirations. It's also an opportunity to begin to demonstrate the creative and independent thinking required of a successful scientist.
    Not yet on the job market? Just starting out as a postdoc? A research plan isn't just for demonstrating; it's also for honing and refining. It's possible to function quite well as a postdoc or grad student while giving little thought to your future. Writing a research plan casts your gaze forward and prompts you to begin planning for when you have your own laboratory. And if you've already started to think about your own lab, it will help you to refine your plans. So take a stab at writing a research plan, even if you don't expect to be on the job market for a while. Think of it as a rough draft, a fantasy trip for your career.
    * * *
    But never mind about that. Most of you are trying to get hired. In that case what matters is, What is the committee looking for?
    The answer: relief from anxiety.
    Hiring committees desperately want to avoid making a serious mistake by investing institutional and intellectual capital in the wrong person. The aim of your research plan, then, as of the rest of your application, is to assure the hiring committee that life with you will be pain-free.
    How do you do this? Provide the committee a compelling, reassuring, believable image of what their life will be like when you are working down the hall.
    Tell them a story--a believable, credible story--about what your lab will be like 5 years from now: well-funded, vibrant, productive, pursuing a valuable, ambitious but realistic research agenda that meshes well with the department's mission and with the other research going on in the department.
    Please don't misunderstand: You shouldn't tell them this ("in 5 years my lab will be vibrant, productive, and well-funded ..."; rather, you need to lead them to believe it by describing a research agenda that persuades them that you will succeed. There are two parts to this: You have to tell a good story, and you have to make them believe it. If the story isn't compelling you won't get hired, and if they can't quite imagine it becoming reality, you won't get hired.
    How do I tell a good story?
    * First, choose an important subject. If the research you plan is not compelling, no rhetorical skill will make it compelling to a committee of smart scientists. If the research you propose is not manifestly, obviously important, if you don't know why it's important, or if you can't convey its importance effectively, convincing the committee to hire you won't be easy. Note that there are two issues here: believing in the importance of your own work, and persuading others that your work is important.
    If you don't think the work you'll be doing is important, your best bet is to change fields. The goal of science may be to uncover truth, but uncovering objective truth is a very difficult thing to do, and doing it requires passion. If you aren't passionate about your work, your best bet is to find work about which you can be passionate. It isn't easy to change gears midcourse, but getting yourself into an important area of research will be well worth the effort in the long term--to your hirability, your fundability, your tenurability, and also to your career satisfaction. Do another postdoc if you must.
    Passion for your work is a necessary, but insufficient, condition for capturing the attention of hiring committees. After all, some people are passionate about, um, peculiar things. To convince the committee to hire you, you must convince them that your passion is justified and that they will benefit from investing in your passion--that is, that your work is important.
    * Be specific. Curing cancer is not a suitable goal for one individuals' research plan--exciting, yes, but much too big to be believable. Inhibiting tumor growth? That's better, says one of our respondents--especially when that general goal is supported by more specific strategies. "[That kind of research] can travel down several different mechanistic routes," this respondent says, "i.e., angiogenesis, breakdown of extracellular matrix, gene activation, induction of molecules involved--it can use different models--implanting tumors, using different tumor models, in vivo, in vitro, etc." The combination of a manifestly important goal with manifestly interesting, feasible approaches is the foundation of the research plan.
    Being specific is not the same thing as including loads of detail. Being specific means including only as much detail as the job requires--not more. "Vague generalities are the sign of a vague mind," says one source. "This means that the proposal must walk the fine line of enough detail to show the reader that the candidate knows what they are talking about, but not too much detail that it confuses or bores the search committee."
    * Keep it short and focus on the major themes. "Brevity and clarity are the most important elements," wrote another respondent, expressing a sentiment shared by everyone. "Clear, concise writing ... is a plus," said another. "Superfluous details are not just unnecessary, they are often the hallmark of a poor plan. The specific aims must be clear and succinct." Identify your goals, state why those goals are important, define your approach to achieving those goals, and indicate the kinds of evidence that will validate your approach. Oh, and do it clearly and succinctly.
    "If you were sitting for 4 hours reading such proposals, what would you look for? Clear and to the point wins every time in this arena."
    Effective communication requires anticipating readers' needs, giving them exactly the information they need just when they need it. Constructing a research plan along these lines strengthens your application in three ways: You avoid alienating the committee by boring them; you tell the committee precisely what you intend to do; and you show that you have a subtle mind and a deep knowledge of your field.
    Can't do this yet? No hurry--consider spending another year as a postdoc, and study hard.
    * Be serious about writing. Writes one respondent: "If the proposal confuses the reader in almost any way, it is simply tossed out. I strongly recommend that the candidate have colleagues pre-review the proposal and make sure the English is clear and ideas explained so that a variety of people in the general area can understand what is being proposed and the importance of the work."
    If your writing skills are weak, it might be time to strengthen them. Or hire an editor. And by all means have several people--preferably senior colleagues who have served on hiring committees--critique your research plan.
    But there were two parts to this, remember? You not only have to tell a good story--you also have to make it seem real, to make them expect it to come true.
    How do I make my research plan seem real?
    * Have a solid, well-considered, realistic plan. If you want to get a job at an institution that takes its research seriously, you'll have to convince your future colleagues that you've gotten past the young, impressionable phase, where every idea glitters with promise despite the fact that it isn't feasible and isn't likely to work. Show the committee that, while your high ideals remain intact, your years of graduate and postdoctoral study have helped you to know the difference between good ideas and good intentions. In the words of one scholar, "You can tell a 'building castles in the sky' research plan. They are not built on solid data and go to the very bottom of the pool." Indeed ...
    * Include preliminary data. Preliminary data offer the most convincing argument for the viability of your research plan. If you have them, use them--positive results will be of interest and persuasive to hiring committee members. The nature of your preliminary data and findings will vary--some will have much to share, others might be forced to share very preliminary data.
    Nothing grounds your hopes and dreams in the real world like good, solid data. Your plan might sound exciting, but will it work? It's one thing to make it sound good; if you can show that you've already taken the first, tentative but successful steps of that long journey, reaching your destination will seem a lot less like a pipe dream. One of my sources was unequivocal on this point: "Does the research question build on the preliminary data the person has generated? No preliminary data = no research question." Which also equals no job offer at that institution.
    It is important to remember that just as institutions vary widely in their practices, so too do the expectations of hiring committees. Do your homework: Learn about the culture of the department and the experiences of previous faculty hires.
    * Include redundant approaches. If you want to succeed as a scientist you have to be resourceful. You can't be a one-trick pony. And the focus must be on the science--on the problem you aim to solve--not on the scientist or a particular approach. No matter how knowledgeable you are, no matter how well considered your research plan, you can't predict the future. And if you haven't done the work yet, you don't know how it will turn out. That means that any one approach you specify might not work, even if it seems compelling. So if you want to convince the committee that you will succeed, give them not one, but two, or even three, compelling approaches, all of which have a good chance of success.
    How do I demonstrate my independence?
    Different institutions expect you to be at different stages of your career. Think of it as a continuum: At one end sit well-established researchers with strong research records, many first-author (or last-author) publications, and their own research funding. At the other end sit rosy-cheeked freshly minted Ph.D.s full of enthusiasm, promise, and ideas, but with little yet to show for it. Most candidates for entry-level tenure-track faculty jobs at institutions that require research (that is, most of the people who write research plans for job applications) are somewhere in the middle. You probably won't get hired anywhere if you aren't well prepared to start a productive research program at a scale appropriate for the institution.
    But these days some institutions and departments are looking for more than that. Increasingly, especially in the biomedical field, universities are hiring established researchers, even at the "entry" (assistant professor) level. How is this possible? These days some pre-tenure-track scientists are setting up their own research programs. Increasingly, senior postdocs are being promoted to research associate or research faculty positions during what the GrantDoctor calls the "postpostdoc" phase of their research career. In that position they write research grants in their own names and their host institutions sponsor them. Very often these folks have an R01 before they begin applying for a tenure-track job.
    The key objective if you’re applying to one of these institutions is securing research grants: If you have a grant in your own name you'll be a strong candidate; if you don't have your own grant, you are less competitive. It's a cynical copout on the institution’s part, really, taking a pass on the difficult job of evaluating talent and capitulating to the reality of big-time biomedical research: It's all about the cash. Still, increasingly it's a fact of life. But how do you know if the institution to which you hope to apply is one of these? Ask.
    Those scientists and institutions--the ones sitting at the experienced far end of the continuum--are exceptional. Indeed, second-tier research institutions tend to expect the most experience; Harvard and Johns Hopkins do not expect you to have your own research grant. Most hiring committees aren't looking for completely independent work; they're looking for original, creative ideas, together with a record of accomplishment. Few people applying for tenure-track jobs have had the opportunity to start their own research programs. After all, traditionally that's what assistant professorships are all about, and most institutions still think that way. It helps to be somewhere in the middle of that continuum, but most committees are still looking more for promise than for guarantees.
    Demonstrate your promise by displaying your potential and actual independence. Show the committee that you have the deep thinking and talent to operate independent of your adviser.
    How do you demonstrate your independence when you have never been given the chance to work independently?
    Likely as not, all your data were collected in someone else's lab, as a part of someone else's research agenda. How, then, do you distinguish your research from your adviser's research?
    * On paper. It's an apparent Catch-22: You need to show that your ideas are fresh, new, and yours, and you have to show they're grounded in work you've already done, usually in someone else's lab. It's a tough sell, but most of your competitors are in the same boat.
    So how do you do it? One respondent said it beautifully: "The best plans usually build on the prior experience of the applicant, but are not direct extensions of their postdoctoral work."
    I'm going to type that phrase again, it's so important: The best plans usually build on the prior experience of the applicant, but are not direct extensions of their postdoctoral work.
    Unless you're one of the select few applicants with lots of experience leading your own lab, that's the key to your rhetorical strategy. That's the outline of the story you must tell: "I did this work as a grad student/postdoc and it was important and it was great. Now, as a faculty member, I want to do something a little bit different, but the work I'm proposing takes full advantage of the knowledge and skills I gained during the training phase of my career." It's different enough to be original, but similar enough that your years of training aren't wasted.
    Another respondent wrote, "Most candidates (95%) stick to extensions of what they are most familiar with, but the key is, have they figured out some rather creative new directions for the research and have they done a good job convincing us that they can do it based on what is already known?" "Once we have a short list of candidates," writes yet another source, "the research proposals are looked at more carefully for imaginative ideas that differ from the candidates’ Ph.D. or postdoctoral research." Get the message?
    * With your adviser's cooperation. One key to doing this successfully is to make sure your boss tells the same story. Hopefully you have a good, open relationship with your adviser; if you do, go in and chat and coordinate your strategies. Decide what turf is his or hers, what turf is yours, and what story you intend to tell in your research plan and his or her letter of recommendation. But make sure they don't match too precisely.
    Is this sort of coordination unethical? Hardly. There's no deception here, no attempt to pull the wool over the committee's eyes. On the contrary, it's clarity you're seeking: in your relationship with your adviser and with the hiring committee.
    Be careful though: This is tricky ethical territory. The ideas you're claiming must be yours. Don't just take your adviser's ideas and package them as your own, even if your adviser signs off on the plan.
    If your relationship with your adviser isn't so chummy, you still want to do these same things; you just want to do it more carefully.
    * If you still have time, set up your own lab in the corner of your adviser's. If you aren't applying for jobs right now, there's still time. Talk to your adviser about carving out your own research niche within the larger research effort, where you do work motivated by your own original ideas, something related but oblique to what your adviser is doing in the rest of the lab.
    Is the research plan more important in the screening phase or late in the game?
    In general, research plans are weighed more heavily later in the game, with more readily comprehensible evidence (especially pedigree, letters of recommendation, impact factor of journals, etc.) being weighed more heavily in the early rounds.
    However, your research plan must be designed to serve more than one purpose. It must withstand intense scrutiny in the later rounds of the job search, and it must make a good first impression.
    * * *
    How long should it be?
    Opinions vary. One person I spoke to said that a research plan should be "about three pages of 1.5-spaced text, and NEVER more than five." Another source prefers "three semi-independent (but related) subproposals not more than about three to four pages (single-spaced) each with a half page of important and relevant references." That's nine to 12 pages. There is some variation from one discipline to the next (the first of these recommendations came from a medical school, the second from a department of chemistry), but there are few if any standards even within a field. This shows how much of a crap shoot getting hired can be: Because you usually don't know in advance how long a document the hiring committee is looking for, there's little chance of the same candidate, no matter how qualified, getting offers from both of these institutions.
    My recommendation? Call the chair of the hiring committee (or send e-mail) and ask for advice. If no advice is forthcoming, aim for five pages, 12-point Times New Roman, 1.5 spaced. Some will think it's a bit too long, others a bit too short, but no one will throw it out because of its length.
    Remember that we said that a research plan needs to help you through initial screening and withstand careful scrutiny in the later stages.